Astilbin

Astilbin - High-Purity Natural Dihydroflavonol for Nutraceutical & Pharmaceutical Applications

Pharmaceutical-grade Astilbin (CAS 298-81-7) from Engelhardtia roxburghiana is available from Kingherbs Limited at 30% to 80% purity. Food-grade ethanol extraction at regulated temperatures preserves chiral integrity and prevents isomerization in our production process. Our 25 years of botanical extraction knowledge ensures source-to-shipment traceability from verified planting bases to HPLC verification. Clear chromatograms show Neoastilbin and Isoastilbin separation in each batch, with residual solvent levels below ICH Q3C limits. Our ready-stock inventory supports your formulation timeframes with constant USP, EP, and CP quality and 3–5 business day delivery for sample orders and commercial volumes.

What is Astilbin?

Astilbin is a bioactive dihydroflavonol glycoside. The taxifolin backbone of this naturally occurring molecule has a rhamnose sugar unit, providing it distinct pharmacokinetic characteristics compared to the aglycone version.

This substance is mostly derived from Smilax glabra Roxb. rhizomes and Engelhardia roxburghiana leaves. The formula is C₂₁H₂₂O₁₁ with a molecular weight of 450.41 g/mol.

Selective immunomodulation makes this chemical intriguing. Instead of broad-spectrum immunosuppressants, it targets helper T-cell activity and decreases TNF-α and IL-6 production without affecting the immune system.

The compound is a white to light yellow crystalline powder with 180–182°C melting point. You benefit from its poor oral bioavailability (0.30% in animal studies) because it accumulates in the intestinal system and modulates gut microbiota and intestinal barrier function.

Astilbin Certificate of Analysis (COA)

Complete COA with HPLC chromatogram provided with each batch.

Astilbin Benefits

Gut-Bone Axis Support

This chemical links gut health to bone density in a unique way. Research shows it regulates the UPP1-MAPK signaling pathway to decrease body weight, improve lipid profiles, and strengthen trabecular bone.

Selective Immunomodulation

Specific T-cell modulation without the nephrotoxicity of immunosuppressants like cyclosporine A. This makes it useful for autoimmune formulations.

Protection of the liver

The substance protects against liver fibrosis and alcoholic fatty liver disease by inhibiting the TGF-β1/Smad pathway. Its liver tissue affinity concentrates activity where you need it.

Restore Intestinal Barrier

Low systemic absorption keeps it active in the gut, where it heals barrier damage, restores microbial diversity, and decreases dangerous bacteria.

Antioxidants and Anti-Inflammation

It prevents lipid peroxidation and UV-induced skin damage by scavenging reactive oxygen species and inhibiting hyaluronidase.

Astilbin Applications

Food Supplements

Liver, gut microbiota, and bone health supplements may be made. In "hangover defense" formulations, the chemical works well under metabolic stress from alcohol.

Pharmaceutical Development

For APIs targeting rheumatoid arthritis, lupus, psoriasis, and allergic contact dermatitis. You may treat T-cell-mediated illnesses while maintaining general immunity using its selective strategy.

Cosmetics that function

It may be added to hypoallergenic, anti-aging, and UV-protective serums. In emulsions, it prevents lipid peroxidation and reduces environmental stressor erythema.

Drink Mixtures

Despite low water solubility, cyclodextrin complexes or polysorbate solubilizers may be used to make clear beverages or botanical suspensions.

Certifications

Kingherbs maintains comprehensive quality and safety certifications:

• ISO 9001 – Quality Management System
• FSSC 22000 – Food Safety System Certification
• HACCP – Hazard Analysis Critical Control Points
• KOSHER – Kosher Certification
• HALAL – Halal Certification
• Organic (EU & USDA) – Available upon request
• FDA Registration – US facility registration
• HNBEA Member – Hunan Botanical Extract Association Council Member

All certifications are current and available for review upon request.

FAQ

Q: Why does the product's poor bioavailability assist gut health?

A: Our product has a poor oral bioavailability of about 0.30% in rats. It may accumulate in the colon and interact with gut flora, therefore this is a benefit. Studies suggest it repaired intestinal barrier damage, restored microbial diversity, and reduced dangerous bacteria.

Q: What makes these products distinct in preventing obesity-related bone loss?

A: Unlike traditional bone health supplements, this product utilizes a "gut-bone axis" process. It improves gut microbiota, bone mineral density, and trabecular structure while reducing weight and dyslipidemia. By modulating the UPP1-MAPK axis, it promotes bone-forming cells and suppresses fat-forming cells.

Q: Is the product safe for human use?

A: A 4-week oral toxicity trial in rats demonstrated no deleterious effects at dosages up to 500 mg/kg/day—the NOAEL was more than 500 mg/kg. Multiple testing showed no genotoxicity. However, pure product powder might cause mild to severe skin and eye irritation, so handle carefully.

Q: Can you modify specifications?

A: Yes. We provide unique blends, ratio extracts, and specification tweaks for your recipe. We provide stability testing and formulation improvement at our application lab.

Q: What about formulation stability?

A: High heat and alkaline pH affect the chemical. We suggest storage in cold, dry settings at pH 4.0–6.5. We offer technical documentation and accelerated stability data (40°C/75% RH).

Packaging and Transportation

Standard Packaging:

• 25 kg/fiber drum with double food-grade PE bags inside
• Custom packaging available for trial orders

Storage Conditions:

• Store in cool, dry place away from direct sunlight
• Recommended temperature: below 25°C
• Keep containers tightly sealed

Transportation Options:

• Express Courier – For samples and small quantities (3–5 days)
• Air Freight – For urgent commercial orders
• Ocean Freight – For bulk shipments (most economical)

Minimum Order Quantity:

• Samples and trial orders (kg quantities) welcome
• Commercial orders: 25 kg

Delivery Time:

• Ready stock available for immediate shipment
• Sample orders: 3–5 business days
• Commercial orders: prompt delivery from existing inventory

Why Choose Kingherbs?

25+ Years of Manufacturing Excellence

We've been a top Chinese botanical extraction manufacturer since 1996, strengthening our capabilities.

Full Source Traceability

From seed selection to soil management to harvest time, we regulate quality. This prevents raw material variations and maintains active ingredient content.

Clean-Extraction Technology

Free of hazardous solvents, our procedure employs pure water or food-grade ethanol. Clean color, rapid solubility, and optimal safety.

Tech Formulation Support

We provide solutions, not ingredients. Our application laboratory helps with stability testing and optimization of beverage, gummy, pill, and cosmetic formulations.

Clear Quality Documentation

Clear HPLC chromatograms indicate perfect isomeric separation in each batch. For international compliance, we follow USP, EP, BP, and CP.

One-stop buying

In addition to plant extracts, we provide vitamins, minerals, amino acids, and chemicals. Small trial orders with variable MOQs are welcome. We provide premixes, softgels, capsules, and more.

Secret Innovation Partnership

We work on innovative substances and unique formulae under stringent confidentiality agreements to speed up product development and market launch.

Our Warehouse

Our Exhibitions

Contact Us

Ready to discuss your formulation needs with Astilbin? Get technical specifications, samples, or quotations by reaching out to our team at info@kingherbs.com today.