Views: 100 Author: Site Editor Publish Time: 2025-07-09 Origin: Site
Mangiferin is a polyphenolic compound extracted from the leaves and fruits of mango as well as some other plants (e.g., Zhi Mu, Momordica charantia, etc.).Let’s follow Kingherbs to learn about the wide range of biological activities and pharmacological effects of mangiferin.
The following is a detailed description of its main effects:
1. Antioxidant effects
- Scavenging of free radicals: Mangiferin effectively scavenges reactive oxygen species (e.g., superoxide anion, hydroxyl radical, etc.) in the body and reduces cellular damage caused by oxidative stress.
- Protection of cell structure: through the inhibition of lipid peroxidation, to protect cell membranes, proteins and DNA from oxidative damage, delaying cell aging.
2. Anti-inflammatory effect
- inhibit inflammatory factors: it can down-regulate the expression of inflammatory mediators (such as tumor necrosis factor TNF-α, interleukin IL-6, IL-1β, etc.) and reduce inflammatory reactions.
- Regulation of inflammatory pathway: It can block the inflammatory cascade reaction by inhibiting inflammatory signaling pathway such as NF-κB, which has potential alleviating effect on chronic inflammation such as arthritis and enteritis.
3. Hypoglycemia and improvement of metabolism
- Regulation of blood glucose level: Studies have shown that mangiferin can promote insulin secretion, improve insulin sensitivity, inhibit intestinal absorption of glucose, which helps to lower blood glucose, and has a certain auxiliary effect on diabetes mellitus and its complications (e.g., retinopathy, nephropathy).
- Regulate lipid metabolism: It can reduce the content of triglyceride and cholesterol in blood, improve the state of high blood lipid, and reduce the risk of atherosclerosis.
4. Hepatoprotective effect
- Reduce liver damage: Protect liver cells from damage caused by chemicals (e.g. alcohol, drugs) or toxins through antioxidant and anti-inflammatory effects, and promote liver cell repair.
- Improve liver function: It can reduce the level of serum transaminases (ALT, AST), regulate the metabolic function of the liver, and have certain auxiliary protective effect on fatty liver and other liver diseases.
5. Immunomodulation
- Enhancement of immune function: It can promote the activity of immune cells (such as macrophages, T lymphocytes) and improve the body's ability to resist infection. - Balance immune response: in autoimmune diseases, it may reduce the damage to tissues caused by excessive immune response by regulating immune balance.
6. Neuroprotective effects
- Anti-neurodegenerative diseases: Its antioxidant properties can reduce oxidative damage to nerve cells, which may have potential preventive or mitigating effects on neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
- Improvement of cognitive function: Some studies suggest that mangiferin may improve learning and memory by regulating neurotransmitters (e.g. acetylcholine) in the brain.
7. Other potential effects
- Anti-tumor: In vitro studies have shown that mangiferin has inhibited proliferation and induced apoptosis in some tumor cells (e.g., lung and liver cancer cells), but its in vivo anti-tumor effect still needs further study.
- Antibacterial and antiviral: It has certain inhibitory effect on some bacteria (such as Staphylococcus aureus) and viruses (such as influenza virus).
- Cardiovascular protection: Indirectly protects the endothelial function of blood vessels and reduces the risk of cardiovascular disease through antioxidant and lipid-lowering effects.
Precautions:
The pharmacological effects of mangiferin are mostly based on animal experiments and in vitro studies, and its specific efficacy and safe dosage in humans still need to be verified in more clinical trials.
- As a natural compound, its effects are usually supportive and not a substitute for medication (e.g., diabetes, liver disease, etc., on medical advice).
- Some people may be allergic to them and caution should be exercised when using mangiferin-containing preparations. In conclusion, mangiferin has the potential to be used in the field of health products and pharmaceutical research and development due to its various biological activities, but the specific application should be combined with scientific research and professional guidance.
Kingherbs provides a large amount of Mango Leaf Extract- Mangiferin to customers all over the world every year. Our products can meet the different needs of customers.Contact us at info@kingherbs.com to know more about our products and their uses.
